The identification of resveratrol, a compound found in grapes and other plants, and its connection to the protein NQO2 illustrates the power underlying the commitment to scientific pursuit and exploration.
Discovery of Resveratrol in Grapes: Resveratrol was first isolated and characterized in the 1940s from the roots of the Japanese knotweed plant. Subsequently, its presence in grapes gained attention in part due to the "French Paradox" phenomenon, evident by lower rates of cardiovascular diseases in the French population despite consumption of a diet rich in saturated fats.
Health Benefits of Resveratrol: Research into resveratrol's health benefits expanded rapidly in the late 20th century. Studies suggested that resveratrol exhibited antioxidant properties and could potentially reduce the risk of heart disease, cancer, and other age-related conditions. Its ability associated with longevity and cellular health, garnered significant interest in the scientific community.
Identification of Resveratrol Target Protein NQO2: In the early 2000s, scientists began to explore the molecular mechanisms underlying resveratrol's effects. One breakthrough came when researchers identified NAD(P)H:quinone oxidoreductase 2 (NQO2) as a target protein for resveratrol. NQO2, also known as QR2, is an enzyme involved in detoxification pathways and cellular redox regulation.
Publications from 1978 to now
https://en.wikipedia.org/wiki/Resveratrol
https://pubmed.ncbi.nlm.nih.gov/?term=resveratrol
Publications from 1961 to now
https://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase,_quinone_2
Reference Work • Third Edition • Volume 1, 2021, Pages 649-665 Regulation | Quinone Reductase 2: From Classical Role in Detoxification to Emerging Role as a Novel Regulator of Cellular Activities
https://www.sciencedirect.com/science/article/abs/pii/B9780128194607000864?via%3Dihub