Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

• Antioxidant, antimutagen

• Anti-carcinogenesis activity: anti-initiation, antipromotion and anti-progression

• Present in human diet; potential cancer-preventive agent

Published date: 1997 Jan

Journal: Science

Citation by (up to 6/2025): 6983

Link: https://pubmed.ncbi.nlm.nih.gov/8985016/

Crystal structure of quinone reductase 2 in complex with resveratrol

• Potent inhibitor of NQO2/QR2 activity with a dissociation constant of 35 nM

• Binding affinity suggests potential interaction with other polyphenols like quercetin

• Implication: Resveratrol's benefits may stem from NQO2/QR2 inhibition, leading to increased cellular resistance to oxidative stress

Published date: 2004 Sep

Journal: Biochemistry

Citation (up to 6/2025): 289

Link: https://pubmed.ncbi.nlm.nih.gov/15350128/